{"id":84839,"date":"2021-11-09T13:41:25","date_gmt":"2021-11-09T11:41:25","guid":{"rendered":"https:\/\/www.technion.ac.il\/blog\/emergency-pathway-saves-cells-with-protein-damage\/"},"modified":"2021-11-09T13:41:25","modified_gmt":"2021-11-09T11:41:25","slug":"emergency-pathway-saves-cells-with-protein-damage","status":"publish","type":"post","link":"https:\/\/www.technion.ac.il\/en\/blog\/emergency-pathway-saves-cells-with-protein-damage\/","title":{"rendered":"Emergency Pathway Saves Cells with Protein Damage"},"content":{"rendered":"<p>An international research team headed by Technion scientists has found an alternative manner for eliminating damaged proteins when the cells are impaired by \u201coxygen radicals,\u201d as can happen in failing human hearts where there is poor cell respiration and cells become oxygen depleted, or suffer \u201chypoxia,\u201d because of poor oxygen uptake.<\/p>\n<p>Significantly, the researchers discovered that there can be a shift from the tightly controlled process of eliminating proteins in the cells to a less strict mechanism when cells enter an \u201cemergency protocol.\u201d This shift can \u201cclear up\u201d the toxic proteins before their toxicity levels get too high.<\/p>\n<figure id=\"attachment_46926\" aria-describedby=\"caption-attachment-46926\" style=\"width: 300px\" class=\"wp-caption aligncenter\"><a href=\"https:\/\/www.technion.ac.il\/wp-content\/uploads\/2021\/11\/1-9-scaled.jpg\"><img decoding=\"async\" class=\"wp-image-46926 size-medium\" src=\"https:\/\/www.technion.ac.il\/wp-content\/uploads\/2021\/11\/1-9-300x200.jpg\" alt=\"L-R: Professor Oded Kleifeld, Professor Michael Glickman and Professor Ashraf Brik\" width=\"300\" height=\"200\" \/><\/a><figcaption id=\"caption-attachment-46926\" class=\"wp-caption-text\">L-R: Prof. Oded Kleifeld, Prof. Michael Glickman and Prof. Ashraf Brik<\/figcaption><\/figure>\n<p>Their study was published on 26 October 2021 in <a href=\"https:\/\/www.nature.com\/articles\/s41467-021-26427-0\" target=\"_blank\" rel=\"noopener\"><em>Nature Communication<\/em><\/a><em>. <\/em>To carry out their study, the researchers investigated several \u201cproteasomes,\u201d protein complexes that work by a chemical reaction to degrade unneeded or damaged cell proteins. The researchers found that elevated levels of one type of proteasome, 20S, appears to contribute to cell survival, even for those cells under stress from damaged proteins.<\/p>\n<p>Human cells &#8211; both functional and damaged &#8211; are constantly recycled by chemically \u201ctagging\u201d and targeting for removal when they are under stress by the ubiquitin system (2004 Nobel Prize in chemistry).\u00a0At the same time, a few proteins that are intact and functional can also be dragged into the 20S proteasome \u201cmolecular disposal unit\u201d along with the toxic proteins that have be targeted for destruction. Nevertheless, rather than harm cells, this mode of action by 20S proteasome may aid cells in rapidly remove toxic proteins. In their conclusion, the authors raised the interesting speculation that this emergency pathway can help even damaged cells to withstand bouts of stress and allow them to \u201cage gracefully\u201d.<\/p>\n<figure id=\"attachment_46925\" aria-describedby=\"caption-attachment-46925\" style=\"width: 300px\" class=\"wp-caption aligncenter\"><a href=\"https:\/\/www.technion.ac.il\/wp-content\/uploads\/2021\/11\/2-5-scaled.jpg\"><img decoding=\"async\" class=\"wp-image-46925 size-medium\" src=\"https:\/\/www.technion.ac.il\/wp-content\/uploads\/2021\/11\/2-5-300x212.jpg\" alt=\"Professor Michael Glickman (left) and Professor Indrajit Sahu\" width=\"300\" height=\"212\" \/><\/a><figcaption id=\"caption-attachment-46925\" class=\"wp-caption-text\">Professor Michael Glickman (left) and Dr. Indrajit Sahu<\/figcaption><\/figure>\n<p>To carry out the study, Technion researchers Dr. Indrajit Sahu, Prof. Michael Glickman, Prof. Ashraf Brik, and Prof. Oded Kleifeld worked with Prof. Sharlene Day from the University of Pennsylvania and the research team of Prof. Yao Cong of the Chinese Academy of Sciences in Shanghai, China.<\/p>\n<p><a href=\"https:\/\/www.nature.com\/articles\/s41467-021-26427-0\" target=\"_blank\" rel=\"noopener\">Click here<\/a><strong> for the paper in Nature Communications<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>An international research team headed by Technion scientists has found an alternative manner for eliminating damaged proteins when the cells are impaired by \u201coxygen radicals,\u201d as can happen in failing human hearts where there is poor cell respiration and cells become oxygen depleted, or suffer \u201chypoxia,\u201d because of poor oxygen uptake. Significantly, the researchers discovered&hellip; <a class=\"continue\" href=\"https:\/\/www.technion.ac.il\/en\/blog\/emergency-pathway-saves-cells-with-protein-damage\/\">Continue Reading<span> Emergency Pathway Saves Cells with Protein Damage<\/span><\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[24],"tags":[],"class_list":["post-84839","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.4 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Emergency Pathway Saves Cells with Protein Damage - \u05d4\u05d8\u05db\u05e0\u05d9\u05d5\u05df-\u05de\u05db\u05d5\u05df \u05d8\u05db\u05e0\u05d5\u05dc\u05d5\u05d2\u05d9 \u05dc\u05d9\u05e9\u05e8\u05d0\u05dc<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.technion.ac.il\/en\/blog\/emergency-pathway-saves-cells-with-protein-damage\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Emergency Pathway Saves Cells with Protein Damage - \u05d4\u05d8\u05db\u05e0\u05d9\u05d5\u05df-\u05de\u05db\u05d5\u05df \u05d8\u05db\u05e0\u05d5\u05dc\u05d5\u05d2\u05d9 \u05dc\u05d9\u05e9\u05e8\u05d0\u05dc\" \/>\n<meta property=\"og:description\" content=\"An international research team headed by Technion scientists has found an alternative manner for eliminating damaged proteins when the cells are impaired by \u201coxygen radicals,\u201d as can happen in failing human hearts where there is poor cell respiration and cells become oxygen depleted, or suffer \u201chypoxia,\u201d because of poor oxygen uptake. 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\u05d4\u05d8\u05db\u05e0\u05d9\u05d5\u05df-\u05de\u05db\u05d5\u05df \u05d8\u05db\u05e0\u05d5\u05dc\u05d5\u05d2\u05d9 \u05dc\u05d9\u05e9\u05e8\u05d0\u05dc","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.technion.ac.il\/en\/blog\/emergency-pathway-saves-cells-with-protein-damage\/","og_locale":"en_US","og_type":"article","og_title":"Emergency Pathway Saves Cells with Protein Damage - \u05d4\u05d8\u05db\u05e0\u05d9\u05d5\u05df-\u05de\u05db\u05d5\u05df \u05d8\u05db\u05e0\u05d5\u05dc\u05d5\u05d2\u05d9 \u05dc\u05d9\u05e9\u05e8\u05d0\u05dc","og_description":"An international research team headed by Technion scientists has found an alternative manner for eliminating damaged proteins when the cells are impaired by \u201coxygen radicals,\u201d as can happen in failing human hearts where there is poor cell respiration and cells become oxygen depleted, or suffer \u201chypoxia,\u201d because of poor oxygen uptake. Significantly, the researchers discovered&hellip; Continue Reading Emergency Pathway Saves Cells with Protein Damage","og_url":"https:\/\/www.technion.ac.il\/en\/blog\/emergency-pathway-saves-cells-with-protein-damage\/","og_site_name":"\u05d4\u05d8\u05db\u05e0\u05d9\u05d5\u05df-\u05de\u05db\u05d5\u05df \u05d8\u05db\u05e0\u05d5\u05dc\u05d5\u05d2\u05d9 \u05dc\u05d9\u05e9\u05e8\u05d0\u05dc","article_published_time":"2021-11-09T11:41:25+00:00","author":"shelleys","twitter_card":"summary_large_image","twitter_misc":{"Written by":"shelleys","Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.technion.ac.il\/en\/blog\/emergency-pathway-saves-cells-with-protein-damage\/","url":"https:\/\/www.technion.ac.il\/en\/blog\/emergency-pathway-saves-cells-with-protein-damage\/","name":"Emergency Pathway Saves Cells with Protein Damage - \u05d4\u05d8\u05db\u05e0\u05d9\u05d5\u05df-\u05de\u05db\u05d5\u05df \u05d8\u05db\u05e0\u05d5\u05dc\u05d5\u05d2\u05d9 \u05dc\u05d9\u05e9\u05e8\u05d0\u05dc","isPartOf":{"@id":"https:\/\/www.technion.ac.il\/en\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.technion.ac.il\/en\/blog\/emergency-pathway-saves-cells-with-protein-damage\/#primaryimage"},"image":{"@id":"https:\/\/www.technion.ac.il\/en\/blog\/emergency-pathway-saves-cells-with-protein-damage\/#primaryimage"},"thumbnailUrl":"https:\/\/www.technion.ac.il\/wp-content\/uploads\/2021\/11\/1-9-300x200.jpg","datePublished":"2021-11-09T11:41:25+00:00","author":{"@id":"https:\/\/www.technion.ac.il\/en\/#\/schema\/person\/49775ab0ed8d52cd013f2f1277a09881"},"breadcrumb":{"@id":"https:\/\/www.technion.ac.il\/en\/blog\/emergency-pathway-saves-cells-with-protein-damage\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.technion.ac.il\/en\/blog\/emergency-pathway-saves-cells-with-protein-damage\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.technion.ac.il\/en\/blog\/emergency-pathway-saves-cells-with-protein-damage\/#primaryimage","url":"https:\/\/www.technion.ac.il\/wp-content\/uploads\/2021\/11\/1-9-300x200.jpg","contentUrl":"https:\/\/www.technion.ac.il\/wp-content\/uploads\/2021\/11\/1-9-300x200.jpg"},{"@type":"BreadcrumbList","@id":"https:\/\/www.technion.ac.il\/en\/blog\/emergency-pathway-saves-cells-with-protein-damage\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home Page","item":"https:\/\/www.technion.ac.il\/en\/"},{"@type":"ListItem","position":2,"name":"Emergency Pathway Saves Cells with Protein Damage"}]},{"@type":"WebSite","@id":"https:\/\/www.technion.ac.il\/en\/#website","url":"https:\/\/www.technion.ac.il\/en\/","name":"\u05d4\u05d8\u05db\u05e0\u05d9\u05d5\u05df-\u05de\u05db\u05d5\u05df \u05d8\u05db\u05e0\u05d5\u05dc\u05d5\u05d2\u05d9 \u05dc\u05d9\u05e9\u05e8\u05d0\u05dc","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.technion.ac.il\/en\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/www.technion.ac.il\/en\/#\/schema\/person\/49775ab0ed8d52cd013f2f1277a09881","name":"shelleys","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.technion.ac.il\/en\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/38ed48a7d51c57ef37d3ea0915ab39449c118f93badf34d989045f7f5c861c40?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/38ed48a7d51c57ef37d3ea0915ab39449c118f93badf34d989045f7f5c861c40?s=96&d=mm&r=g","caption":"shelleys"},"url":"https:\/\/www.technion.ac.il\/en\/blog\/author\/shelleys\/"}]}},"_links":{"self":[{"href":"https:\/\/www.technion.ac.il\/en\/wp-json\/wp\/v2\/posts\/84839","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.technion.ac.il\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.technion.ac.il\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.technion.ac.il\/en\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/www.technion.ac.il\/en\/wp-json\/wp\/v2\/comments?post=84839"}],"version-history":[{"count":0,"href":"https:\/\/www.technion.ac.il\/en\/wp-json\/wp\/v2\/posts\/84839\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.technion.ac.il\/en\/wp-json\/wp\/v2\/media?parent=84839"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.technion.ac.il\/en\/wp-json\/wp\/v2\/categories?post=84839"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.technion.ac.il\/en\/wp-json\/wp\/v2\/tags?post=84839"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}