{"id":84712,"date":"2021-02-06T20:20:44","date_gmt":"2021-02-06T18:20:44","guid":{"rendered":"https:\/\/www.technion.ac.il\/blog\/new-pathway-to-attack-cancer-cells\/"},"modified":"2021-02-06T20:20:44","modified_gmt":"2021-02-06T18:20:44","slug":"new-pathway-to-attack-cancer-cells","status":"publish","type":"post","link":"https:\/\/www.technion.ac.il\/en\/blog\/new-pathway-to-attack-cancer-cells\/","title":{"rendered":"New\u200c \u200cPathway\u200c \u200cto \u200cAttack\u200c \u200cCancer\u200c \u200cCells\u200c \u200c"},"content":{"rendered":"

When\u200c \u200ctreating\u200c \u200ccancer,\u200c \u200cresearchers\u200c \u200care\u200c \u200calways\u200c \u200csearching\u200c \u200cfor\u200c \u200cways\u200c \u200cto\u200c \u200cremove\u200c \u200ccancer\u200c \u200ccells\u200c \u200cwhile\u200c \u200cminimizing\u200c \u200cdamage\u200c \u200cto\u200c \u200cthe\u200c \u200crest\u200c \u200cof\u200c \u200cthe\u200c \u200cbody.\u200c One\u200c \u200cpossible\u200c \u200capproach\u200c \u200cis\u200c \u200cto\u200c \u200cfind\u200c \u200cprocesses\u200c \u200cunique\u200c \u200cto\u200c \u200ccancer\u200c \u200ccells,\u200c \u200cand\u200c \u200cwhich\u200c \u200cwould\u200c \u200callow\u200c \u200cspecific\u200c \u200ctargeting.\u200c \u200cIf\u200c \u200csuch\u200c \u200ca\u200c \u200cprocess\u200c \u200ccan\u200c \u200cbe\u200c \u200cdisrupted,\u200c \u200conly\u200c \u200cthose\u200c \u200ccells\u200c \u200cwould\u200c \u200cbe\u200c \u200caffected.\u200c \u200c<\/p>\n

\"\"<\/a><\/p>\n

A\u200c \u200cprocess\u200c \u200c(or\u200c \u200cabsence\u200c \u200cthereof)\u200c \u200ccan\u200c \u200cbe\u200c \u200cunique\u200c \u200cto\u200c \u200csome\u200c \u200ctypes\u200c \u200cof\u200c \u200ccancer,\u200c \u200cand\u200c \u200cnot\u200c \u200cbe\u200c \u200cpresent\u200c \u200cin\u200c \u200cothers.\u200c \u200cIn\u200c \u200csuch\u200c \u200ca\u200c \u200ccase,\u200c \u200cwe\u200c \u200cwould\u200c \u200cwant\u200c \u200ca\u200c \u200csimple\u200c \u200cway\u200c \u200cto\u200c \u200crecognize\u200c \u200cwhether\u200c \u200ca\u200c \u200cparticular\u200c tumor\u200c \u200cpossesses\u200c \u200cthe\u200c \u200cunique\u200c \u200ctrait\u200c \u200cor\u200c \u200cnot.\u200c \u200cThe\u200c \u200cimplication\u200c \u200cof\u200c \u200cthis\u200c \u200cquestion\u200c \u200cis\u200c \u200cwhether\u200c \u200cthe\u200c \u200ctumor\u200c \u200cwould\u200c respond\u200c \u200cto\u200c \u200cthis\u200c \u200cor\u200c \u200cthat\u200c \u200ctreatment,\u200c \u200callowing\u200c \u200cus\u200c \u200cto\u200c \u200cmatch\u200c \u200ca\u200c \u200ctreatment\u200c \u200cto\u200c \u200cthe\u200c \u200cpatient\u200c \u200cwho\u200c \u200cis\u200c \u200clikely\u200c \u200cto\u200c \u200cbe\u200c \u200chelped\u200c \u200cby\u200c \u200cit,\u200c \u200crather\u200c \u200cthan\u200c \u200cgoing\u200c \u200cby\u200c \u200ctrial\u200c \u200cand\u200c \u200cerror.\u200c \u200c<\/p>\n

Professor\u200c \u200cTomer\u200c \u200cShlomi\u2019s\u200c \u200cresearch\u200c \u200cgroup\u200c \u200cdiscovered\u200c \u200cjust\u200c \u200csuch\u200c \u200ca\u200c \u200cprocess\u200c \u200c\u2013\u200c \u200cone\u200c \u200cthat\u200c \u200cmay\u200c \u200cbe\u200c \u200ctargeted\u200c \u200cin\u200c \u200ccancer\u200c \u200ccells\u200c \u200cwithout\u200c \u200ccausing\u200c \u200cdamage\u200c \u200cto\u200c \u200chealthy\u200c \u200cones\u200c. The \u200cfindings\u200c \u200c\u200chave\u200c \u200cbeen\u200c \u200cpublished\u200c \u200cin\u200c \u200c\u200cCell\u200c \u200cMetabolism\u200c.\u200c \u200c<\/p>\n

The\u200c \u200cfolate\u200c \u200ccycle\u200c \u200cis\u200c \u200ca\u200c \u200cprocess\u200c \u200cessential\u200c \u200cto\u200c \u200cDNA\u200c \u200cand\u200c \u200cRNA\u200c \u200cproduction.\u200c \u200cAs\u200c \u200ca\u200c \u200cresult,\u200c \u200cit\u200c \u200cis\u200c \u200chighly\u200c \u200cimportant\u200c \u200cto\u200c \u200cboth\u200c \u200ccancer\u200c \u200ccells\u200c \u200cand\u200c \u200chealthy\u200c \u200ccells.\u200c Because\u200c \u200cDNA\u200c \u200cproduction\u200c \u200cis\u200c \u200ca\u200c \u200ccritical\u200c \u200cstage\u200c \u200cin\u200c \u200ccell\u200c \u200cdivision,\u200c \u200cand\u200c \u200cthus\u200c \u200cin\u200c \u200ctumor\u200c \u200cgrowth,\u200c \u200cthe\u200c \u200cfolate\u200c \u200ccycle\u200c \u200cis\u200c \u200ca\u200c \u200ccommon\u200c \u200ctarget\u200c \u200cfor\u200c \u200cchemotherapy.\u200c \u200cHowever,\u200c \u200cfor\u200c \u200cthe\u200c \u200cvery\u200c \u200csame\u200c \u200creason,\u200c \u200cthere\u200c \u200care\u200c \u200csignificant\u200c \u200cside\u200c \u200ceffects\u200c \u200cto\u200c \u200cattacking\u200c \u200cit.\u200c \u200c<\/p>\n

There\u200c \u200care,\u200c \u200cin\u200c \u200cfact,\u200c \u200ctwo\u200c \u200cfolate\u200c \u200ccycles\u200c \u200c\u2013\u200c \u200cone\u200c \u200chappening\u200c \u200cin\u200c \u200cthe\u200c \u200cmitochondria\u200c \u200c(an\u200c \u200corganelle\u200c \u200cinside\u200c \u200cthe\u200c \u200ccell),\u200c \u200cand\u200c \u200cone\u200c \u200cin\u200c \u200cthe\u200c \u200ccytosol\u200c \u200c(the\u200c \u200cfluid\u200c \u200cthat\u200c \u200cfills\u200c \u200cthe\u200c \u200ccell).\u200c \u200cA\u200c \u200chealthy\u200c \u200ccell\u200c \u200ccan\u200c \u200cswitch\u200c \u200cfrom\u200c \u200cone\u200c \u200cto\u200c \u200cthe\u200c \u200cother.\u200c \u200cProfessor\u200c \u200cShlomi\u2019s\u200c \u200cgroup\u200c \u200cdiscovered that a\u200c \u200cvariety\u200c \u200cof\u200c \u200ctumor\u200c \u200ccells\u200c \u200crely\u200c \u200cexclusively on\u200c \u200cthe\u200c \u200ccytosolic\u200c \u200cpathway\u200c.\u200c \u200cThis implies that \u200cif\u200c \u200ctreatment\u200c \u200cwere\u200c \u200cto\u200c \u200ctarget\u200c \u200cthe\u200c \u200ccytosolic\u200c \u200cfolate\u200c \u200ccycle,\u200c \u200chealthy\u200c \u200ccells\u200c \u200cwould\u200c \u200cswitch\u200c \u200cto\u200c \u200cthe\u200c \u200cmitochondrial\u200c \u200ccycle\u200c \u200cand\u200c \u200cwould\u200c \u200cnot\u200c \u200cbe\u200c \u200charmed,\u200c \u200cleaving\u200c \u200ctumor\u200c \u200ccells\u200c \u200cto\u200c \u200cdie.\u200c \u200c<\/p>\n

Recognition would still be needed of whether\u200c \u200ca\u200c \u200cparticular\u200c \u200ctumor\u200c \u200cis\u200c \u200cindeed\u200c \u200cone\u200c \u200cin\u200c \u200cwhich\u200c \u200cthe\u200c \u200cmitochondrial\u200c \u200cfolate\u200c \u200ccycle\u200c \u200cis\u200c \u200cnon-functional,\u200c \u200cand\u200c \u200chere\u200c \u200ctoo,\u200c \u200cShlomi\u2019s\u200c \u200cteam\u200c \u200cis bringing insights.\u200c \u200cRFC\u200c \u200cis\u200c \u200ca\u200c \u200ctransporter\u200c \u200cprotein\u200c \u200cthat\u200c \u200cregulates\u200c \u200cintracellular\u200c \u200cfolate\u200c \u200clevels.\u200c \u200cA low\u200c \u200cRFC\u200c \u200cequals\u200c \u200clow\u200c \u200cfolate levels.\u200c \u200cThe\u200c \u200cgroup\u200c \u200cdiscovered that low levels of folates are \u200cdevastating\u200c \u200cto\u200c \u200cthe\u200c \u200cmitochondrial\u200c \u200ccycle;\u200c so\u200c \u200clow\u200c \u200cRFC\u200c \u200ctumors\u200c \u200care\u200c \u200cthose \u200c\u200cthat\u200c \u200cwould\u200c \u200cbe\u200c \u200caffected\u200c \u200cby\u200c \u200ccytosolic\u200c \u200ccycle-blocking\u200c \u200ctreatments.\u200c \u200c<\/p>\n

For\u200c \u200cthe\u200c \u200cfull\u200c \u200carticle\u200c \u200con\u200c \u200c\u200cCell\u200c \u200cMetabolism\u200c\u200c \u200c\u200cclick\u200c \u200chere\u200c.\u200c \u200c<\/strong><\/span><\/a>
\n\u200c<\/p>\n","protected":false},"excerpt":{"rendered":"

When\u200c \u200ctreating\u200c \u200ccancer,\u200c \u200cresearchers\u200c \u200care\u200c \u200calways\u200c \u200csearching\u200c \u200cfor\u200c \u200cways\u200c \u200cto\u200c \u200cremove\u200c \u200ccancer\u200c \u200ccells\u200c \u200cwhile\u200c \u200cminimizing\u200c \u200cdamage\u200c \u200cto\u200c \u200cthe\u200c \u200crest\u200c \u200cof\u200c \u200cthe\u200c \u200cbody.\u200c One\u200c \u200cpossible\u200c \u200capproach\u200c \u200cis\u200c \u200cto\u200c \u200cfind\u200c \u200cprocesses\u200c \u200cunique\u200c \u200cto\u200c \u200ccancer\u200c \u200ccells,\u200c \u200cand\u200c \u200cwhich\u200c \u200cwould\u200c \u200callow\u200c \u200cspecific\u200c \u200ctargeting.\u200c \u200cIf\u200c \u200csuch\u200c \u200ca\u200c \u200cprocess\u200c \u200ccan\u200c \u200cbe\u200c \u200cdisrupted,\u200c \u200conly\u200c \u200cthose\u200c \u200ccells\u200c \u200cwould\u200c \u200cbe\u200c \u200caffected.\u200c \u200c A\u200c \u200cprocess\u200c… Continue Reading New\u200c \u200cPathway\u200c \u200cto \u200cAttack\u200c \u200cCancer\u200c \u200cCells\u200c \u200c<\/span><\/a><\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[24],"tags":[],"class_list":["post-84712","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"acf":[],"yoast_head":"\nNew\u200c \u200cPathway\u200c \u200cto \u200cAttack\u200c \u200cCancer\u200c \u200cCells\u200c \u200c - 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