{"id":84701,"date":"2021-01-14T15:42:21","date_gmt":"2021-01-14T13:42:21","guid":{"rendered":"https:\/\/www.technion.ac.il\/blog\/toadlet-peptide-transforms-into-a-deadly-weapon-against-bacteria\/"},"modified":"2021-01-14T15:42:21","modified_gmt":"2021-01-14T13:42:21","slug":"toadlet-peptide-transforms-into-a-deadly-weapon-against-bacteria","status":"publish","type":"post","link":"https:\/\/www.technion.ac.il\/en\/blog\/toadlet-peptide-transforms-into-a-deadly-weapon-against-bacteria\/","title":{"rendered":"Toadlet peptide transforms into a deadly weapon against bacteria"},"content":{"rendered":"

Researchers at Technion \u2013 Israel Institute of Technology and the European Molecular Biology Laboratory (EMBL) in Hamburg, Germany, in collaboration with scientists in Israel and Spain, have discovered remarkable molecular properties of an antimicrobial peptide from the skin of the Australian toadlet. The discovery could inspire the development of novel synthetic drugs to combat bacterial infections.<\/b><\/p>\n

\"\"<\/a>
The peptide uperin 3.5 is secreted by the Australian toadlet\u2019s skin in a \u201cdormant\u201d form, in which the peptide self-assembles into a stable amyloid fibril in the so-called cross-\u03b2 form. When exposed to bacteria, it rapidly changes into cross-\u03b1 fibrils that affect the bacterial membrane, thereby killing the bacteria. The pictures were taken using a transmission electron microscope (TEM) in the Electron Microscopy Centers in the Technion Department of Materials Science and Engineering and in the Department of Chemical Engineering. The cross-\u03b1 atomic structure was determined by data collected at the ESRF synchrotron.<\/figcaption><\/figure>\n

An antibacterial peptide that turns on and off\u00a0<\/b><\/span><\/p>\n

\"\"<\/a>
Professor Meytal Landau<\/figcaption><\/figure>\n

The researchers solved the 3D molecular structure of an antibacterial peptide named uperin 3.5, which is secreted on the skin of the Australian toadlet (<\/span>Uperoleia mjobergii<\/span><\/i>) as part of its immune system. They found that the peptide self-assembles into a unique fibrous structure, which via a <\/span>sophisticated structural adaptation mechanism can change its form in the presence of bacteria to protect the toadlet from infections<\/b>. This provides unique atomic-level evidence explaining a regulation mechanism of an antimicrobial peptide.<\/span><\/p>\n

The antibacterial fibrils on the toadlet\u2019s skin have a structure that is reminiscent of amyloid fibrils, which are a hallmark of neurodegenerative diseases, such as Alzheimer\u2019s and Parkinson\u2019s. Although amyloid fibrils have been considered pathogenic for decades, it has recently been discovered that certain amyloid fibrils can benefit the organisms that produce them, from humans to microbes. For example, certain bacteria produce such fibrils to fight human immune cells.<\/span><\/p>\n

\"\"<\/a>
Dr. Einav Tayeb-Fligelman<\/figcaption><\/figure>\n

The findings suggest that the antibacterial peptide secreted on the toadlet\u2019s skin self-assembles into a \u201cdormant\u201d configuration in the form of highly stable amyloid fibrils, which scientists describe as a cross-\u03b2 conformation. These fibrils serve as a reservoir of potential attacker molecules that can be activated when bacteria are present. Once the peptide encounters the bacterial membrane, it changes its molecular configuration to a less compact cross-\u03b1 form and transforms into a deadly weapon. <\/span>\u201cThis is a sophisticated protective mechanism of the toadlet, induced by<\/b> the<\/b> attacking bacteria themselves,<\/b>\u201d says structural biologist Prof. Meytal Landau, the lead author of this study. \u201cThis is a unique example of an evolutionary design of switchable supramolecular structures to control activity.\u201d<\/span><\/p>\n

Potential for future medical applications<\/b><\/span><\/p>\n

Antimicrobial peptides are found in all kingdoms of life and thus are hypothesized to be commonly used as weapons in nature, occasionally effective in killing not only bacteria but also cancer cells. Moreover, the unique amyloid-like properties of the toadlet\u2019s antibacterial peptide, discovered in this study, shed light on the potential physiological properties of amyloid fibrils associated with neurodegenerative and systemic disorders.<\/span><\/p>\n

\"\"<\/a>
Dr. Nir Salinas<\/figcaption><\/figure>\n

The researchers hope that their discovery will lead to medical and technological applications, e.g. <\/b>development of <\/span>synthetic antimicrobial peptides<\/b> that would be activated only in the presence of bacteria. Synthetic peptides of this kind could also serve as a stable coating for medical devices or implants, or even in industrial equipment that requires sterile conditions.\u00a0<\/span><\/p>\n

The study is a result of a collaboration between scientists at EMBL Hamburg and Technion, and groups in Israel and Spain. It is an example of EMBL\u2019s approach to life science research in its next scientific Programme\u00a0Molecules to Ecosystems. EMBL will integrate interdisciplinary approaches to understand the molecular basis of life in the context of environmental changes, and to provide translational potential to support advances in human and planetary health.<\/span><\/p>\n

For the article in <\/span>PNAS <\/b>click here<\/a><\/strong><\/span><\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Researchers at Technion \u2013 Israel Institute of Technology and the European Molecular Biology Laboratory (EMBL) in Hamburg, Germany, in collaboration with scientists in Israel and Spain, have discovered remarkable molecular properties of an antimicrobial peptide from the skin of the Australian toadlet. 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