{"id":84315,"date":"2018-02-15T12:14:01","date_gmt":"2018-02-15T10:14:01","guid":{"rendered":"https:\/\/www.technion.ac.il\/blog\/orthodontic-surgery-with-an-enzymatic-blade-no-incision-necessary\/"},"modified":"2018-02-15T12:14:01","modified_gmt":"2018-02-15T10:14:01","slug":"orthodontic-surgery-with-an-enzymatic-blade-no-incision-necessary","status":"publish","type":"post","link":"https:\/\/www.technion.ac.il\/en\/blog\/orthodontic-surgery-with-an-enzymatic-blade-no-incision-necessary\/","title":{"rendered":"Orthodontic Surgery with an Enzymatic Blade: No Incision Necessary"},"content":{"rendered":"

Technion researchers have developed a technology that replaces scalpels with natural biological materials<\/b><\/span><\/p>\n

HAIFA, ISRAEL (February 15, 2018) \u2013 Researchers at the Technion-Israel Institute of Technology have developed a nanotechnology that replaces the surgical scalpel with an \u201cenzymatic blade.\u201d In an article published recently in\u00a0ACS Nano<\/a><\/span>, the researchers describe the application of this technology in a surgical procedure in the oral cavity. The application spares the pain associated with orthodontic surgeries and significantly reduces tissue recovery time.<\/strong><\/p>\n

\"Dr.
Dr. Assaf Zinger<\/figcaption><\/figure>\n

The study was led by Dr. Assaf Zinger, within the framework of his doctoral research, mentored by Assistant Professor Avi Schroeder, the director of the Laboratory of Targeted Drug Delivery and Personalized Medicine at the Wolfson Faculty of Chemical Engineering. The novel technology is based on rational use of enzymes \u2013 biological molecules the body uses to repair itself, as well as on use of nanoparticles for achieving a targeted therapeutic profile.<\/span><\/p>\n

In the United States alone, approximately five million people undergo orthodontic treatment each year. To speed up treatment, which typically lasts about two years, many undergo invasive surgery, in which collagen fibers that connect the tooth to the underlying bone tissue are cut.<\/span><\/p>\n

The technology developed at the Technion softens the collagen fibers via the targeted release of collagenase \u2013 an enzyme that specifically breaks down collagen. Using techniques developed in Schroeder\u2019s lab, the collagenase is packaged into liposomes \u2013 nanometric vesicles. As long as the collagenase particles are packaged in the liposome, they are inactive. But with this special nanotechnology, an ointment is applied on the target site, so that the enzyme begins to gradually leak from the liposome and soften the collagen fibers. The researchers performed a series of tests to determine the collagenase concentration optimal for the procedure and to accelerate tissue repair thereafter.<\/span><\/p>\n

\"Assistant
Assistant Professor Avi Schroeder (Credit: Doron Golan)<\/figcaption><\/figure>\n

In a preclinical trial, the researchers compared the efficacy of the controlled-release system (in combination with braces), to that of standard orthodontic treatment and concluded that the system reduces the time required for straightening teeth and improving therapeutic outcome. This would translate to an orthodontic treatment in humans that lasts several months, instead of two years. The researchers estimate that it could be used in humans within a couple of years.<\/span><\/p>\n

While the <\/span>ACS Nano<\/span><\/i> article presents a specific application of the \u201cenzymatic blade\u201d in the orthodontics field, the researchers emphasize that the new paradigm can be applied in a variety of surgical procedures. \u201cOver thousands of years, the surgical knife has been upgraded, however, the general paradigm has not changed. Here, in the current study, we present a considerable paradigm shift: replacing the metal blade with a biological process.\u201d<\/span><\/p>\n

Also taking part in this research collaboration were physicians at the Sourasky Tel Aviv Medical Center Department of Pathology and the Rambam Medical Center Department of Oral Maxillofacial Surgery, and the director of the Moriah Animal Companion Center. The research was supported by grants from the European Council and European Union, German-Israeli Foundation for Scientific Research and Development, various Israeli foundations and Alon and Taub Fellowships.<\/span><\/p>\n

Click <\/b>here<\/b><\/a><\/span> for the paper in ACS Nano<\/b><\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Technion researchers have developed a technology that replaces scalpels with natural biological materials HAIFA, ISRAEL (February 15, 2018) \u2013 Researchers at the Technion-Israel Institute of Technology have developed a nanotechnology that replaces the surgical scalpel with an \u201cenzymatic blade.\u201d In an article published recently in\u00a0ACS Nano, the researchers describe the application of this technology in… Continue Reading Orthodontic Surgery with an Enzymatic Blade: No Incision Necessary<\/span><\/a><\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[24],"tags":[],"class_list":["post-84315","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"acf":[],"yoast_head":"\nOrthodontic Surgery with an Enzymatic Blade: No Incision Necessary - \u05d4\u05d8\u05db\u05e0\u05d9\u05d5\u05df-\u05de\u05db\u05d5\u05df \u05d8\u05db\u05e0\u05d5\u05dc\u05d5\u05d2\u05d9 \u05dc\u05d9\u05e9\u05e8\u05d0\u05dc<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.technion.ac.il\/en\/blog\/orthodontic-surgery-with-an-enzymatic-blade-no-incision-necessary\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Orthodontic Surgery with an Enzymatic Blade: No Incision Necessary - 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