{"id":84106,"date":"2016-04-14T11:44:07","date_gmt":"2016-04-14T08:44:07","guid":{"rendered":"https:\/\/www.technion.ac.il\/blog\/tissue-graft-breakthrough\/"},"modified":"2016-04-14T11:44:07","modified_gmt":"2016-04-14T08:44:07","slug":"tissue-graft-breakthrough","status":"publish","type":"post","link":"https:\/\/www.technion.ac.il\/en\/blog\/tissue-graft-breakthrough\/","title":{"rendered":"Tissue Graft Breakthrough"},"content":{"rendered":"

Technion breakthrough improves chances tissue grafts will survive and thrive<\/strong><\/h2>\n

A better understanding of the effect of mechanical forces on blood vessel assembly in engineered tissues aids optimal growth of new blood vessels after tissue transplantation<\/h4>\n

Researchers from the Technion-Israel Institute of Technology and colleagues in the U.S. have developed technology to tailor grafted tissues that can respond to certain natural forces affecting blood vessels. The researchers also found that matching the structure of the engineered vessels to the structure of the host tissues at the site of implantation helps the tissue implant integration, improving the chances that grafted tissues will survive better. The findings were published recently in The Proceedings of the National Academy of Sciences (PNAS)<\/em>.<\/p>\n

\u201cDeveloping functional and mature three-dimensional (3D) blood vessel networks in implantable tissues is critical when using these engineered tissues to treat a number of conditions, such as cardiovascular disease and trauma injuries,\u201d said lead researcher Prof. Shulamit Levenberg of the Technion Department of Biomedical Engineering. \u201cMatching the tissue structures will improve the long term viability and strength of tissue grafts when new blood vessel growth – called \u2018angiogenesis\u2019 – can be manipulated and exploited for the purpose of attaining optimal blood supply.\u201d<\/p>\n

The team\u2019s laboratory studies were aimed at determining just how vascular networks are regulated by various kinds of \u201ctensile forces\u201d- by stretching the constructs (3D engineered tissues).<\/p>\n

\u201cAlthough mechanical forces play a central role in all biological processes as well as influence the shape and organization of cells, mechanical forces had not been previously investigated in relation to vascular networks in 3D,\u201d explained Prof. Levenberg. \u201cOur study used a number of techniques to monitor the impact of tensile forces on vascular network construction and properties.\u201d<\/p>\n

The researchers examined the effects of cell-induced forces on vascular networks by applying variety of stretching forces, both cyclic (on-and-off) and static (constant) forces.\u00a0 The researchers found that the vessels aligned in response to the stretch.<\/p>\n

To test the effects vessel alignments on tissue integration, the researchers grafted engineered tissues into mouse abdominal muscles with the vessel direction placed both parallel and vertically to the natural mouse muscle fibers (host tissues).\u00a0 They found that tissues with vertically implanted blood vessels had greater stiffness and strength when they corresponded to the vertical direction of the host tissue fibers.<\/p>\n

This study was conducted in collaboration with Professor Dave Mooney, of Harvard University, who hosted Prof. Levenberg during her sabbatical year. The project was carried out by Dr. Dekel Dado-Rosenfeld as part of her PhD thesis, under the mentorship of Prof. Levenberg. Dr. Dado-Rosenfeld is currently a postdoc at the Massachusetts Institute of Technology, under the auspices of the MIT-Technion Post-Doctoral Fellowship<\/p>\n","protected":false},"excerpt":{"rendered":"

Technion breakthrough improves chances tissue grafts will survive and thrive A better understanding of the effect of mechanical forces on blood vessel assembly in engineered tissues aids optimal growth of new blood vessels after tissue transplantation Researchers from the Technion-Israel Institute of Technology and colleagues in the U.S. have developed technology to tailor grafted tissues… Continue Reading Tissue Graft Breakthrough<\/span><\/a><\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[24],"tags":[],"class_list":["post-84106","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"acf":[],"yoast_head":"\nTissue Graft Breakthrough - \u05d4\u05d8\u05db\u05e0\u05d9\u05d5\u05df-\u05de\u05db\u05d5\u05df \u05d8\u05db\u05e0\u05d5\u05dc\u05d5\u05d2\u05d9 \u05dc\u05d9\u05e9\u05e8\u05d0\u05dc<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.technion.ac.il\/en\/blog\/tissue-graft-breakthrough\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Tissue Graft Breakthrough - \u05d4\u05d8\u05db\u05e0\u05d9\u05d5\u05df-\u05de\u05db\u05d5\u05df \u05d8\u05db\u05e0\u05d5\u05dc\u05d5\u05d2\u05d9 \u05dc\u05d9\u05e9\u05e8\u05d0\u05dc\" \/>\n<meta property=\"og:description\" content=\"Technion breakthrough improves chances tissue grafts will survive and thrive A better understanding of the effect of mechanical forces on blood vessel assembly in engineered tissues aids optimal growth of new blood vessels after tissue transplantation Researchers from the Technion-Israel Institute of Technology and colleagues in the U.S. have developed technology to tailor grafted tissues… Continue Reading Tissue Graft Breakthrough\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.technion.ac.il\/en\/blog\/tissue-graft-breakthrough\/\" \/>\n<meta property=\"og:site_name\" content=\"\u05d4\u05d8\u05db\u05e0\u05d9\u05d5\u05df-\u05de\u05db\u05d5\u05df \u05d8\u05db\u05e0\u05d5\u05dc\u05d5\u05d2\u05d9 \u05dc\u05d9\u05e9\u05e8\u05d0\u05dc\" \/>\n<meta property=\"article:published_time\" content=\"2016-04-14T08:44:07+00:00\" \/>\n<meta name=\"author\" content=\"shlomi ben-oz\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"shlomi ben-oz\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.technion.ac.il\/en\/blog\/tissue-graft-breakthrough\/\",\"url\":\"https:\/\/www.technion.ac.il\/en\/blog\/tissue-graft-breakthrough\/\",\"name\":\"Tissue Graft Breakthrough - \u05d4\u05d8\u05db\u05e0\u05d9\u05d5\u05df-\u05de\u05db\u05d5\u05df \u05d8\u05db\u05e0\u05d5\u05dc\u05d5\u05d2\u05d9 \u05dc\u05d9\u05e9\u05e8\u05d0\u05dc\",\"isPartOf\":{\"@id\":\"https:\/\/www.technion.ac.il\/en\/#website\"},\"datePublished\":\"2016-04-14T08:44:07+00:00\",\"author\":{\"@id\":\"https:\/\/www.technion.ac.il\/en\/#\/schema\/person\/d65b78b7a7446bdf9fb69078573b8320\"},\"breadcrumb\":{\"@id\":\"https:\/\/www.technion.ac.il\/en\/blog\/tissue-graft-breakthrough\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.technion.ac.il\/en\/blog\/tissue-graft-breakthrough\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.technion.ac.il\/en\/blog\/tissue-graft-breakthrough\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home Page\",\"item\":\"https:\/\/www.technion.ac.il\/en\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Tissue Graft Breakthrough\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.technion.ac.il\/en\/#website\",\"url\":\"https:\/\/www.technion.ac.il\/en\/\",\"name\":\"\u05d4\u05d8\u05db\u05e0\u05d9\u05d5\u05df-\u05de\u05db\u05d5\u05df \u05d8\u05db\u05e0\u05d5\u05dc\u05d5\u05d2\u05d9 \u05dc\u05d9\u05e9\u05e8\u05d0\u05dc\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.technion.ac.il\/en\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.technion.ac.il\/en\/#\/schema\/person\/d65b78b7a7446bdf9fb69078573b8320\",\"name\":\"shlomi ben-oz\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.technion.ac.il\/en\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/96b13158d164281df14ad8583ec2cb64?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/96b13158d164281df14ad8583ec2cb64?s=96&d=mm&r=g\",\"caption\":\"shlomi ben-oz\"},\"url\":\"https:\/\/www.technion.ac.il\/en\/blog\/author\/ben-ozshlomitechnion-ac-il\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Tissue Graft Breakthrough - \u05d4\u05d8\u05db\u05e0\u05d9\u05d5\u05df-\u05de\u05db\u05d5\u05df \u05d8\u05db\u05e0\u05d5\u05dc\u05d5\u05d2\u05d9 \u05dc\u05d9\u05e9\u05e8\u05d0\u05dc","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.technion.ac.il\/en\/blog\/tissue-graft-breakthrough\/","og_locale":"en_US","og_type":"article","og_title":"Tissue Graft Breakthrough - \u05d4\u05d8\u05db\u05e0\u05d9\u05d5\u05df-\u05de\u05db\u05d5\u05df \u05d8\u05db\u05e0\u05d5\u05dc\u05d5\u05d2\u05d9 \u05dc\u05d9\u05e9\u05e8\u05d0\u05dc","og_description":"Technion breakthrough improves chances tissue grafts will survive and thrive A better understanding of the effect of mechanical forces on blood vessel assembly in engineered tissues aids optimal growth of new blood vessels after tissue transplantation Researchers from the Technion-Israel Institute of Technology and colleagues in the U.S. have developed technology to tailor grafted tissues… Continue Reading Tissue Graft Breakthrough","og_url":"https:\/\/www.technion.ac.il\/en\/blog\/tissue-graft-breakthrough\/","og_site_name":"\u05d4\u05d8\u05db\u05e0\u05d9\u05d5\u05df-\u05de\u05db\u05d5\u05df \u05d8\u05db\u05e0\u05d5\u05dc\u05d5\u05d2\u05d9 \u05dc\u05d9\u05e9\u05e8\u05d0\u05dc","article_published_time":"2016-04-14T08:44:07+00:00","author":"shlomi ben-oz","twitter_card":"summary_large_image","twitter_misc":{"Written by":"shlomi ben-oz","Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.technion.ac.il\/en\/blog\/tissue-graft-breakthrough\/","url":"https:\/\/www.technion.ac.il\/en\/blog\/tissue-graft-breakthrough\/","name":"Tissue Graft Breakthrough - \u05d4\u05d8\u05db\u05e0\u05d9\u05d5\u05df-\u05de\u05db\u05d5\u05df \u05d8\u05db\u05e0\u05d5\u05dc\u05d5\u05d2\u05d9 \u05dc\u05d9\u05e9\u05e8\u05d0\u05dc","isPartOf":{"@id":"https:\/\/www.technion.ac.il\/en\/#website"},"datePublished":"2016-04-14T08:44:07+00:00","author":{"@id":"https:\/\/www.technion.ac.il\/en\/#\/schema\/person\/d65b78b7a7446bdf9fb69078573b8320"},"breadcrumb":{"@id":"https:\/\/www.technion.ac.il\/en\/blog\/tissue-graft-breakthrough\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.technion.ac.il\/en\/blog\/tissue-graft-breakthrough\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.technion.ac.il\/en\/blog\/tissue-graft-breakthrough\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home Page","item":"https:\/\/www.technion.ac.il\/en\/"},{"@type":"ListItem","position":2,"name":"Tissue Graft Breakthrough"}]},{"@type":"WebSite","@id":"https:\/\/www.technion.ac.il\/en\/#website","url":"https:\/\/www.technion.ac.il\/en\/","name":"\u05d4\u05d8\u05db\u05e0\u05d9\u05d5\u05df-\u05de\u05db\u05d5\u05df \u05d8\u05db\u05e0\u05d5\u05dc\u05d5\u05d2\u05d9 \u05dc\u05d9\u05e9\u05e8\u05d0\u05dc","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.technion.ac.il\/en\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/www.technion.ac.il\/en\/#\/schema\/person\/d65b78b7a7446bdf9fb69078573b8320","name":"shlomi ben-oz","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.technion.ac.il\/en\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/96b13158d164281df14ad8583ec2cb64?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/96b13158d164281df14ad8583ec2cb64?s=96&d=mm&r=g","caption":"shlomi ben-oz"},"url":"https:\/\/www.technion.ac.il\/en\/blog\/author\/ben-ozshlomitechnion-ac-il\/"}]}},"_links":{"self":[{"href":"https:\/\/www.technion.ac.il\/en\/wp-json\/wp\/v2\/posts\/84106","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.technion.ac.il\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.technion.ac.il\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.technion.ac.il\/en\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.technion.ac.il\/en\/wp-json\/wp\/v2\/comments?post=84106"}],"version-history":[{"count":0,"href":"https:\/\/www.technion.ac.il\/en\/wp-json\/wp\/v2\/posts\/84106\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.technion.ac.il\/en\/wp-json\/wp\/v2\/media?parent=84106"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.technion.ac.il\/en\/wp-json\/wp\/v2\/categories?post=84106"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.technion.ac.il\/en\/wp-json\/wp\/v2\/tags?post=84106"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}