{"id":83941,"date":"2014-07-13T21:00:44","date_gmt":"2014-07-13T18:00:44","guid":{"rendered":"https:\/\/www.technion.ac.il\/blog\/new-avenues-for-alzeheimers-cure\/"},"modified":"2014-07-13T21:00:44","modified_gmt":"2014-07-13T18:00:44","slug":"new-avenues-for-alzeheimers-cure","status":"publish","type":"post","link":"https:\/\/www.technion.ac.il\/en\/blog\/new-avenues-for-alzeheimers-cure\/","title":{"rendered":"New Avenues for Alzeheimer’s Cure"},"content":{"rendered":"

Technion breakthrough opens new avenues for Alzheimer\u2019s cure<\/h2>\n

HAIFA, ISRAEL and NEW YORK (July 10, 2014) \u2013 Alzheimer\u2019s disease affects approximately 5.2 million people in the United States alone, and it is the nation\u2019s sixth leading cause of death. \u00a0A cure for this insidious killer has so far proven elusive, but that could soon change as a result of a breakthrough at the Technion-Israel Institute of Technology that sheds light on a key mechanism in the accumulation of protein plaques in the tissue of Alzheimer’s disease patients.<\/p>\n

The findings were published online this week by Nature Chemical Biology.<\/strong><\/span><\/a><\/p>\n

“Proteins that constitute major building blocks of our body cells continuously pass through quality control,” explains team leader Prof. Michael Glickman<\/strong><\/span><\/a>, of the Faculty of Biology. “Defective proteins are sent to the proteasome, a molecular machine (found in all of our cells) that eliminates defective proteins by recycling them back to their building blocks. But a small number of them slip through this process. Proteins that evade the proteasome accumulate, and may be harmful when they reach a critical mass, which is often the case at an advanced age.\u201d<\/p>\n

The researchers\u2019 breakthrough findings are centered on UBB +1, a mutation prevalent in Alzheimer\u2019s disease patients. \u00a0The mutation impairs a protein called ubiquitin* that marks other proteins to be dismantled at the proteasome.<\/p>\n

Previously, the prevailing view among scientists was that UBB +1 impairs the functioning of the proteasome itself. \u00a0But in her doctoral dissertation under the guidance of Prof. Glickman, Dr. Daria Krutauz found that in the presence of UBB+1, damaged proteins are apprehended on their way to the proteasome, and accumulate without reaching their final recycling destination. \u00a0As a result, they have more opportunity to form the deadly plaque associated with Alzheimer\u2019s disease.<\/p>\n

“Because our findings run contrary to what was previously believed, this discovery opens new venues for intervention in the hope of developing a cure for Alzheimer’s disease,\u201d says Prof. Glickman.<\/p>\n

The research team was comprised of Prof. Michael Glickman, Dr. Daria Krutauz and Lab Manager Noa Reis, in collaboration with team members in the labs of Prof. David Fushman at the University of Maryland, Prof. Steve Gygi at Harvard Medical School and Prof. Ashraf Brik at Ben Gurion University.<\/p>\n

In the photos: Prof. Michael Glickman, Dr. Daria Krutauz<\/p>\n

* In 2004, Distinguished Professors Avram Hershko and Aaron Ciechanover of the Technion, and Prof. Ernie Rose from the Fox Chase Institute were awarded the Nobel Prize in chemistry for their discovery of ubiquitin.<\/p>\n","protected":false},"excerpt":{"rendered":"

Technion breakthrough opens new avenues for Alzheimer\u2019s cure HAIFA, ISRAEL and NEW YORK (July 10, 2014) \u2013 Alzheimer\u2019s disease affects approximately 5.2 million people in the United States alone, and it is the nation\u2019s sixth leading cause of death. \u00a0A cure for this insidious killer has so far proven elusive, but that could soon change… Continue Reading New Avenues for Alzeheimer’s Cure<\/span><\/a><\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[24],"tags":[],"class_list":["post-83941","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"acf":[],"yoast_head":"\nNew Avenues for Alzeheimer's Cure - \u05d4\u05d8\u05db\u05e0\u05d9\u05d5\u05df-\u05de\u05db\u05d5\u05df \u05d8\u05db\u05e0\u05d5\u05dc\u05d5\u05d2\u05d9 \u05dc\u05d9\u05e9\u05e8\u05d0\u05dc<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.technion.ac.il\/en\/blog\/new-avenues-for-alzeheimers-cure\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"New Avenues for Alzeheimer's Cure - 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