{"id":83818,"date":"2013-02-27T13:20:55","date_gmt":"2013-02-27T11:20:55","guid":{"rendered":"https:\/\/www.technion.ac.il\/blog\/nature-communications-reports-technion-scientists-develop-a-new-approach-for-artificial-stimulation-of-blind-retinas\/"},"modified":"2013-02-27T13:20:55","modified_gmt":"2013-02-27T11:20:55","slug":"nature-communications-reports-technion-scientists-develop-a-new-approach-for-artificial-stimulation-of-blind-retinas","status":"publish","type":"post","link":"https:\/\/www.technion.ac.il\/en\/blog\/nature-communications-reports-technion-scientists-develop-a-new-approach-for-artificial-stimulation-of-blind-retinas\/","title":{"rendered":"Nature Communications reports: Technion Scientists Develop a New Approach for Artificial Stimulation of Blind Retinas"},"content":{"rendered":"

\"4\"Method is based on optogenetics \u2013 a newly developing area in neuroscience, and is a first step towards non-invasive sight restoration in cases of degenerative retinal diseases<\/h2>\n
Scientists from the Faculty of Biomedical Engineering at the Technion developed a novel approach towards non-invasive vision restoration in blind retinas, by combining holography and optogenetics \u2013 a rapidly developing field in neuroscience. The study is published in the multidisciplinary Journal, Nature Communications. \u00a0\u00a0<\/em><\/div>\n

\u201cDegenerative diseases of the outer retina are one of the major causes of blindness in the Western world,\u201d says Professor Shy Shoham. \u201cThese diseases are characterized by degeneration of the photoreceptors, which serve as light sensors, while downstream cellular levels in the retina, and specifically the retinal ganglion cells, are relatively well preserved. Artificial stimulation of these neurons constitutes a potential strategy for getting around the damaged retinal nerve cells.\u00a0 Restoring lost vision to basic functionality levels has become possible recently through invasive surgical insertion of artificial electronic implants that electrically stimulate surviving retina cells, similar to the snail-shaped cochlear implants used to treat the hearing impaired. Our approach is different and attempts to stimulate the surviving retinal cells without the need for direct implants onto the retina, and may eventually make surgery and implants redundant.\u201d<\/p>\n

\u201cOur optogenetic approach relies on genetic expression of ion channels that are light sensitive (proteins derived from algae) in the ganglion cells of the retina,\u201d explains Dr. Inna Reutsky-Gefen, who studied the combination of holography and optogenetics and its application to blind retinas during her doctoral thesis under the mentoring of Professor Shoham, and with assistance from additional study co-authors Lior Golan, Dr. Nairouz Farah, Adi Schejter, Limor Tsur, and Dr. Inbar Brosh. \u201cThe ganglion cells are natively transparent and not light-responsive, but after expressing the channel, transform into light-sensors and may be capable of substituting the function of the photoreceptors. In order to create a coherent visual perception in the brain, we have to be able to activate a large number of neurons simultaneously, just as it works in normal visual processing. In addition, this needs to be achieved with high temporal and spatial precision in order to imitate normal retinal information processing. Our study findings demonstrate that optical stimulation of these cells, with the use of a unique holographic projector, enables simultaneous stimulation of a large group of cells with spatial precision at the level of single retinal cells, which is not possible with electrical stimulation. In this manner we demonstrated, in principle, the first ever holographic photo-stimulation capable of restoring cellular activity similar to intact retinal behavior, as a basis for sight rehabilitation developments.\u201d<\/p>\n

The holographic projection method developed in the study uses diffractive spatial light modulation to generate images at the focal plane. This approach is light-efficient and does not \u201dthrow away\u201d much of the light energy. The researchers emphasize that this efficiency will be particularly useful in more advanced phases, where it will be required to miniaturize the system into a portable component of a retinal “prosthetic” system.<\/p>\n

\u201cApplications of this approach are not limited to vision restoration,\u201d stresses Professor Shoham. \u201cholographic stimulation strategies can permit flexible control of the activity of large cellular networks which artificially express light-sensitive channels, and pave the way towards new medical devices and scientific tools that can help \u201cbreak\u201d the brain\u2019s neural code.”<\/p>\n

The research was funded by a European Research Council Starting Grant to Prof. Shoham.<\/p>\n

Illustration: Conceptual design of a future holographic retinal prosthesis mounted on a pair of glasses. Visual input from miniature video camera\/s is converted in real-time into activation laser holograms projected onto genetically photo-sensitized retinal cells (in the back of the eye. Credit: Inna Gefen, Roman Kanevsky and Shy Shoham<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

Method is based on optogenetics \u2013 a newly developing area in neuroscience, and is a first step towards non-invasive sight restoration in cases of degenerative retinal diseases Scientists from the Faculty of Biomedical Engineering at the Technion developed a novel approach towards non-invasive vision restoration in blind retinas, by combining holography and optogenetics \u2013 a… Continue Reading Nature Communications reports: Technion Scientists Develop a New Approach for Artificial Stimulation of Blind Retinas<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[24],"tags":[],"class_list":["post-83818","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"acf":[],"yoast_head":"\nNature Communications reports: Technion Scientists Develop a New Approach for Artificial Stimulation of Blind Retinas - 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