Breakthrough in Understanding Brain Function
Pioneering research conducted at the Technion-Israel Institute of Technology
proves the importance of individualized models for understanding brain function
New research conducted by Prof. Christophe Bernard and Prof. Viktor Jirsa of Aix Marseille Univ, Inserm, Institut de Neurosciences des Systèmes, Marseille, France and Prof. Itamar Kahn of Technion’s Rappaport Faculty of Medicine demonstrates the importance of personalized brain models. The research team’s findings show that individual variations in the brain’s structural connectome (map of neural connections) define a specific structural fingerprint with a direct impact on the functional organization of individual brains.
By using a connectome-based model approach, Prof. Kahn and his partners aimed to understand the functional organization of the brain by modeling the brain as a dynamic system,
then studying how the functional architecture rises from the underlying structural skeleton. Taking advantage of mice studies, they systematically investigated the informative content of different structural features in explaining the emergence of the functional ones.
Whole brain dynamics intuitively depend upon the internal wiring of the brain; but to which extent the individual structural connectome constrains the corresponding functional connectome is unknown, even though its importance is uncontested. After acquiring structural MRI data from individual mice, the researchers virtualized their brain networks and simulated in silico functional MRI data. Theoretical results were validated against empirical awake functional MRI data obtained from the same mice. As a result, the researchers were able to demonstrate that individual structural connectomes predict the functional organization of individual brains.
While structural MRI is a common non-invasive method that can estimate structural connectivity in individual humans and rodents, it is not as precise as the gold standard connectivity mapping possible in the mouse. Utilizing precise mapping available in mice, the authors identified which missing connections (not measurable with structural MRI) are important for whole brain dynamics in the mouse. The researchers identified that individual variations thus define a specific structural fingerprint with a direct impact upon the functional organization of individual brains, a key feature for personalized medicine.
For the full article in PNAS click here