Figure legend: Immuno-fluorescence imaging of young (right) or senescent (left) heat-shocked fibroblasts, where two central transcription factors (TFs), ATF6 (green) and HSF1 (red), were stained. While in young cells, both TFs enter the nucleus, a necessary step for the activation of an optimal transcriptional response to stress, in senescent cells both factors do not fully enter the nucleus. Additionally, HSF1 generates a special punctae structure in young cells, which is optimal for transcriptional activation, but in senescent cells these structures are disorganized.

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