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The subject of research in Dr. Ciechanover's
group involves the elucidation of the mode of action and regulation of
the ubiquitin system for intracellular protein degradation .
They are interested in the possible relation between the basic cellular process and the pathogenesis of malignancies and immune disorders. Specifically , they use molecular, biochemical and cellular approaches toi study the mechanisms involved in the degradation of ncoproteins , tumor suppressors , and transcriptional activators and the mode of processing of antigens presented on class I MHC molecules. |